Carboplatin and oxaliplatin are both platinum(II) diamines, similar to cisplatin, which are widely used in chemotherapy to treat a wide variety of cancers. However, their use is often plagued with severe toxicity and the development of resistance, which leads to disease progression. Recently, oxoplatin, iproplatin, ormaplatin and satraplatin are Pt complexes that have been used clinically or in clinical trials.
Fig. 1.1
Give the following information for the complexes.
oxidation number of the platinum ion ..................................................
shape of the complexes ..................................................
One isomer of the [Pt(NH3)2Cl2(OH)2] complex oxoplatin is shown in part (a) Fig. 1.1.
Complete three-dimensional diagrams to show the shape of the other oxoplatin stereoisomers and indicate the chiral one(s).
Platinum complexes can be considered prodrugs that are intracellularly activated to kill cancer cells.
Cis-platin can be produced by the reduction of the prodrug cis, trans, cis-[PtCl2(OCOCH3)2(NH3)2], which has a similar structure to satraplatin.
Draw the structure of cis, trans, cis-[PtCl2(OCOCH3)2(NH3)2].
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