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Edexcel International A Level Biology

Revision Notes

Home / International A Level / Biology / Edexcel / Revision Notes / 5. Energy Flow, Ecosystems & the Environment / Environmental Biology / 5.23 Mutation, Natural Selection & Evolution


5.23 Mutation, Natural Selection & Evolution


Mutation, Natural Selection & Evolution

  • Species do not stay the same over time; the species that we see around us today have developed over millions of years
    • This process of species change is known as evolution
  • Evolution can be defined as changes in the heritable characteristics of organisms over generations
    • Heritable characteristics are those that can be inherited by, or passed on to, the next generation
      • Changes in characteristics that are not inherited, e.g. a plant having its leaves eaten, do not lead to evolution
    • Heritable characteristics are determined by the alleles of genes that are present in an individual
    • Alleles may change as a result of random mutation, causing them to become more or less advantageous
  • Heritable characteristics that are advantageous are more likely to be passed on to offspring, leading to a gradual change in a species over time
    • This is the process of natural selection 

Natural Selection

  • Natural selection can be defined as the process by which organisms that are better adapted to their environment survive, reproduce, and pass on their advantageous alleles, causing advantageous characteristics to increase in frequency within a population
  • Natural selection involves the following stages
    • Variation exists between individuals in a population
      • Natural selection can only take place if variation is present
      • Variation results from small differences in DNA base sequences between individual organisms within a population
      • Sources of variation include
        • Mutation
        • Meiosis
        • Random fertilisation during sexual reproduction
    • In any habitat there are environmental factors that affect survival chances
      • E.g. predation, competition for food, and disease
      • Environmental factors that influence survival chances are said to act as selection pressures
    • In any population, due to the variation present, some individuals will have characteristics that make them better adapted for survival in the face of any selection pressures
      • This is sometimes described as 'survival of the fittest'
    • Individuals that are well adapted and survive into adulthood are more likely to find a mate and reproduce, producing many offspring
      • Individuals that are less well adapted do not survive long into adulthood are likely to reproduce less often than those that survive for longer, so producing fewer offspring
        • These individuals may not reach adulthood and so do not get the chance to reproduce at all
    • This means that they are more likely to pass on the alleles that code for these advantageous characteristics to their offspring
      • Note that non-heritable characteristics are not passed on to offspring
        • Non-heritable characteristics are those acquired during the lifetime of an organism e.g. gaining weight after eating lots of nuts and berries in autumn, or being injured by a predator
    • The number of individuals in a population with a particular favourable characteristic will increase over time; the characteristic is said to increase in frequency
    • Eventually this favourable characteristic will become the most common of its kind in the population; the population can be said to have adapted to its environment by the process of natural selection
      • While favourable characteristics increase in frequency by natural selection, unfavourable characteristics decrease in frequency by the same process
      • Individuals with unfavourable characteristics are less likely to survive, reproduce, and pass on the alleles for their characteristics, so unfavourable characteristics are eventually lost from the population

An example of natural selection in rabbits

  • Variation in fur colour exists within a rabbit population
    • One allele code for brown fur and another for white fur
  • Rabbits have natural predators, such as foxes, which act as a selection pressure
  • The brown rabbits are more likely to survive and reproduce due to having more effective camouflage
  • When the brown rabbits reproduce, they pass on their alleles to their offspring
  • The frequency of brown fur alleles in the population will increase
  • Over many generations, the frequency of brown fur will increase and the frequency of white fur will decrease

White and brown rabbits natural selection

Selection pressures acting on a rabbit population for one generation; predation by foxes causes the frequency of brown fur in rabbits to increase and the frequency of white fur in rabbits to decrease

Exam Tip

Remember that evolution occurs as a result of natural selection, a process that acts on randomly occurring variation; it does not occur as a direct, purposeful response to an environment. Avoid any statements that imply that evolution occurs 'so that' an organism can survive in its environment. Instead, it is correct to say that evolution occurs by natural selection as a result of random variation in populations.

You should be able to apply the process of natural selection to any scenario that you are presented with in an exam, as with the rabbit example above. Remember the following essential stages

  1. Variation is present in a population
  2. Selection pressures affect a population
  3. Those with advantageous alleles are more likely to survive and reproduce
  4. Advantageous alleles are passed to offspring
  5. Advantageous alleles become more frequent in the population


  • 1. Molecules, Transport & Health
    • Biological Molecules
      • 1.1 The Importance of Water
        • 1.2 Saccharides
          • 1.3 Core Practical 1: Estimating the Concentration of Sugars & Starch
            • 1.4 Condensation & Hydrolysis
              • 1.5 Triglycerides & Ester Bonds
              • The Circulatory System
                • 1.6 The Need for a Circulatory System
                  • 1.7 Blood Vessels: Structure & Function
                    • 1.8 The Cardiac Cycle
                      • 1.9 The Role of Haemoglobin
                        • 1.10 Atherosclerosis
                          • 1.11 Blood Clotting
                          • Diet & Health
                            • 1.12 Reducing Risk Factors of CVD
                              • 1.13 Dietary Antioxidants & CVD
                                • 1.14 Core Practical 2: Investigate the Vitamin C Content of Food & Drink
                                  • 1.15 Interpreting Data on Risk Factors
                                    • 1.16 Designing Studies into the Effects of Risk Factors
                                      • 1.17 Perception of Risk vs Actual Risk
                                        • 1.18 Data on Cholesterol & Lipoproteins
                                          • 1.19 Data on Effect of Diet
                                            • 1.20 Treatments for CVD: Benefits & Risks
                                          • 2. Membranes, Proteins, DNA & Gene Expression
                                            • Gas Exchange, Cell Membranes & Transport
                                              • 2.1 Properties of Gas Exchange Surfaces
                                                • 2.2 Cell Membranes
                                                  • 2.3 Core Practical 3: Investigating Membrane Structure & Permeability
                                                    • 2.4 Osmosis
                                                      • 2.5 Diffusion, Facilitated Diffusion & Active Transport
                                                      • Proteins
                                                        • 2.6 Amino Acids, Proteins & Protein Structure
                                                          • 2.7 Enzymes: Roles & Modes of Action
                                                            • 2.8 Core Practical 4: Investigating the Rate of Enzyme Reactions
                                                              • 2.9 Nucleotides, DNA & RNA, Base Pairing
                                                              • DNA & Gene Expression
                                                                • 2.10 DNA Replication
                                                                  • 2.11 The Nature of the Genetic Code
                                                                    • 2.12 How Bases Code for a Polypeptide Chain
                                                                      • 2.13 Transcription & Translation
                                                                      • Inheritance
                                                                        • 2.14 Mutations
                                                                          • 2.15 Patterns of Inheritance & Sex Linkage
                                                                            • 2.16 Cystic Fibrosis
                                                                              • 2.17 Genetic Screening
                                                                                • 2.18 Ethical & Social Issues of Genetic Screening
                                                                              • 3. Cell Structure, Reproduction & Development
                                                                                • Cell Structure & Organisation
                                                                                  • 3.1 Cell Theory
                                                                                    • 3.2 Levels of Organisation of Cells
                                                                                      • 3.3 Eukaryotic Cells
                                                                                        • 3.4 The Rough Endoplasmic Reticulum & Golgi
                                                                                          • 3.5 Prokaryotic Cells
                                                                                            • 3.6 Electron Microscopy of Animal Cells
                                                                                              • 3.7 Microscopy: Magnification & Resolution
                                                                                                • 3.8 Core Practical 5: Light Microscopy
                                                                                                • Reproduction & Inheritance
                                                                                                  • 3.9 Gene Locus
                                                                                                    • 3.10 Meiosis & Variation
                                                                                                      • 3.11 Mammalian Gametes
                                                                                                        • 3.12 Fertilisation: Mammals
                                                                                                          • 3.13 Fertilisation: Flowering Plants
                                                                                                            • 3.14 The Cell Cycle & Mitosis
                                                                                                              • 3.15 Core Practical 6: Observing the Stages of Mitosis
                                                                                                                • 3.16 Calculation of Mitotic Index
                                                                                                                  • 3.17 Stem Cells & Cell Potency
                                                                                                                    • 3.18 Cell Specialisation
                                                                                                                      • 3.19 Post-Transcriptional Changes to mRNA
                                                                                                                        • 3.20 Gene Interaction & Epigenetics
                                                                                                                          • 3.21 Polygenic Inheritance & Continuous Variation
                                                                                                                        • 4. Plant Structure & Function, Biodiversity & Conservation
                                                                                                                          • Plant Structure & Function
                                                                                                                            • 4.1 Plant Cell Structure
                                                                                                                              • 4.2 Electron Microscopy of Plant Cells
                                                                                                                                • 4.3 Starch & Cellulose: Structure & Function
                                                                                                                                  • 4.4 Properties of Cellulose
                                                                                                                                    • 4.5 The Vascular Structure of Plants
                                                                                                                                      • 4.6 Core Practical 7: Identifying Tissue Types Within Stems
                                                                                                                                      • Plants & Conservation
                                                                                                                                        • 4.7 Plant-Based Products for Sustainability
                                                                                                                                          • 4.8 Water & Inorganic Ions in Plants
                                                                                                                                            • 4.9 Core Practical 8: Determining the Tensile Strength of Plant Fibres
                                                                                                                                            • Plants & Bacterial Growth
                                                                                                                                              • 4.10 Bacterial Growth Conditions
                                                                                                                                                • 4.11 Plant Products with Antimicrobial Properties
                                                                                                                                                  • 4.12 Core Practical 9: Antimicrobial Properties of Plants
                                                                                                                                                    • 4.13 Development of Drugs & Drug Testing
                                                                                                                                                    • Classification & Biodiversity
                                                                                                                                                      • 4.14 The Three Domains of Life
                                                                                                                                                        • 4.15 The Variety of Life
                                                                                                                                                          • 4.16 Biodiversity & Endemism
                                                                                                                                                            • 4.17 Species Richness & Heterozygosity Index
                                                                                                                                                              • 4.18 Index of Biodiversity
                                                                                                                                                                • 4.19 Ecological Niches & Adaptations
                                                                                                                                                                  • 4.20 Hardy-Weinberg Equation
                                                                                                                                                                    • 4.21 Roles of Seed Banks & Zoos in Conservation
                                                                                                                                                                  • 5. Energy Flow, Ecosystems & the Environment
                                                                                                                                                                    • Photosynthesis
                                                                                                                                                                      • 5.1 Photosynthesis: Overview
                                                                                                                                                                        • 5.2 The Role of ATP in Photosynthesis
                                                                                                                                                                          • 5.3 Photosynthesis: Light-Dependent Stage
                                                                                                                                                                            • 5.4 Photosynthesis: Light-Independent Stage
                                                                                                                                                                              • 5.5 Chloroplasts
                                                                                                                                                                                • 5.6 Absorption & Action Spectra
                                                                                                                                                                                  • 5.7 Separation of Photosynthetic Pigments with Chromatography
                                                                                                                                                                                    • 5.8 Core Practical 10: Rate of Photosynthesis
                                                                                                                                                                                    • Ecosystems
                                                                                                                                                                                      • 5.9 Ecological Productivity
                                                                                                                                                                                        • 5.10 Energy & Biomass Transfers
                                                                                                                                                                                          • 5.11 Ecology: Key Terms
                                                                                                                                                                                            • 5.12 Factors Affecting Populations
                                                                                                                                                                                              • 5.13 Niche
                                                                                                                                                                                                • 5.14 Core Practical 11: Quadrat & Transect Study
                                                                                                                                                                                                  • 5.15 Ecological Succession
                                                                                                                                                                                                  • Environmental Biology
                                                                                                                                                                                                    • 5.16 Evidence for Climate Change
                                                                                                                                                                                                      • 5.17 Anthropogenic Climate Change
                                                                                                                                                                                                        • 5.18 Carbon Cycle & Environmental Management
                                                                                                                                                                                                          • 5.19 Models for Predicting Climate Change
                                                                                                                                                                                                            • 5.20 How Climate Change Affects Species
                                                                                                                                                                                                              • 5.21 The Effect of Temperature on Enzyme Reactions
                                                                                                                                                                                                                • 5.22 Core Practical 12: Effect of Temperature on Development
                                                                                                                                                                                                                  • 5.23 Mutation, Natural Selection & Evolution
                                                                                                                                                                                                                    • 5.24 Isolation & Speciation
                                                                                                                                                                                                                      • 5.25 Contentious Issues in Environmental Science
                                                                                                                                                                                                                        • 5.26 Examples of Sustainable Conservation
                                                                                                                                                                                                                      • 6. Microbiology, Immunity & Forensics
                                                                                                                                                                                                                        • Microbiology
                                                                                                                                                                                                                          • 6.1 Culturing Microorganisms
                                                                                                                                                                                                                            • 6.2 Measuring the Growth of Microorganisms
                                                                                                                                                                                                                              • 6.3 The Bacterial Growth Curve
                                                                                                                                                                                                                                • 6.4 Core Practical 13: Rate of Growth of Microorganisms
                                                                                                                                                                                                                                  • 6.5 Comparison of Bacterial & Viral Structure
                                                                                                                                                                                                                                  • Immunity
                                                                                                                                                                                                                                    • 6.6 Tuberculosis & HIV
                                                                                                                                                                                                                                      • 6.7 Pathogens: Routes of Entry
                                                                                                                                                                                                                                        • 6.8 Non-Specific Immune Responses
                                                                                                                                                                                                                                          • 6.9 Specific Immune Responses
                                                                                                                                                                                                                                            • 6.11 Developing Immunity
                                                                                                                                                                                                                                              • 6.12 Pathogens vs Hosts: An Evolutionary Race
                                                                                                                                                                                                                                              • Antibiotics
                                                                                                                                                                                                                                                • 6.13 Antibiotics
                                                                                                                                                                                                                                                  • 6.14 Core Practical 14: The Effects of Different Antibiotics
                                                                                                                                                                                                                                                    • 6.15 Current Usage of Antibiotics
                                                                                                                                                                                                                                                    • Decomposition & Decay
                                                                                                                                                                                                                                                      • 6.16 The Role of Microorganisms
                                                                                                                                                                                                                                                      • Forensics
                                                                                                                                                                                                                                                        • 6.17 Polymerase Chain Reaction
                                                                                                                                                                                                                                                          • 6.18 Gel Electrophoresis in Forensics
                                                                                                                                                                                                                                                            • 6.19 DNA Profiling
                                                                                                                                                                                                                                                              • 6.20 Types of Data Provided by Forensic Analysis
                                                                                                                                                                                                                                                            • 7. Respiration, Muscles & the Internal Environment
                                                                                                                                                                                                                                                              • Respiration
                                                                                                                                                                                                                                                                • 7.1 Overview of Respiration
                                                                                                                                                                                                                                                                  • 7.2 Glycolysis
                                                                                                                                                                                                                                                                    • 7.3 Link Reaction & Krebs Cycle
                                                                                                                                                                                                                                                                      • 7.4 The Electron Transport Chain
                                                                                                                                                                                                                                                                        • 7.5 Anaerobic Respiration
                                                                                                                                                                                                                                                                          • 7.6 Respiratory Quotient
                                                                                                                                                                                                                                                                            • 7.7 Core Practical 15: Investigation of Respiration in Yeast
                                                                                                                                                                                                                                                                              • 7.8 Core Practical 16: Respirometer to Calculate RQ
                                                                                                                                                                                                                                                                              • Muscular Movement
                                                                                                                                                                                                                                                                                • 7.9 The Musculoskeletal System
                                                                                                                                                                                                                                                                                  • 7.10 The Muscle Fibre
                                                                                                                                                                                                                                                                                    • 7.11 The Process of Skeletal Muscle Contraction
                                                                                                                                                                                                                                                                                      • 7.12 The Role of Muscle in the Cardiac Cycle
                                                                                                                                                                                                                                                                                        • 7.13 Calculation of Cardiac Output
                                                                                                                                                                                                                                                                                          • 7.14 The Role of Adrenaline
                                                                                                                                                                                                                                                                                            • 7.15 Core Practical 17: The Effects of Exercise
                                                                                                                                                                                                                                                                                            • The Internal Environment
                                                                                                                                                                                                                                                                                              • 7.16 Negative & Positive Feedback
                                                                                                                                                                                                                                                                                                • 7.17 Homeostasis
                                                                                                                                                                                                                                                                                                  • 7.18 The Kidney: Structure
                                                                                                                                                                                                                                                                                                    • 7.19 Urea as a Waste Product
                                                                                                                                                                                                                                                                                                      • 7.20 Selective Reabsorption in the Kidney
                                                                                                                                                                                                                                                                                                        • 7.21 Hormones in Osmoregulation
                                                                                                                                                                                                                                                                                                          • 7.22 Control of Gene Expression
                                                                                                                                                                                                                                                                                                        • 8. Coordination, Response & Gene Technology
                                                                                                                                                                                                                                                                                                          • The Nervous System
                                                                                                                                                                                                                                                                                                            • 8.1 Neurones: Types and Functions
                                                                                                                                                                                                                                                                                                              • 8.2 How a Response is Generated by Effectors
                                                                                                                                                                                                                                                                                                                • 8.3 The Reflex Arc
                                                                                                                                                                                                                                                                                                                  • 8.4 The Nerve Impulse
                                                                                                                                                                                                                                                                                                                    • 8.5 Myelination & Saltatory Conduction
                                                                                                                                                                                                                                                                                                                      • 8.6 Synapses & Neurotransmitters
                                                                                                                                                                                                                                                                                                                        • 8.7 The Effects of Drugs on Nervous Transmission
                                                                                                                                                                                                                                                                                                                          • 8.8 Detection of Stimuli
                                                                                                                                                                                                                                                                                                                            • 8.9 Habituation
                                                                                                                                                                                                                                                                                                                              • 8.10 Central & Peripheral Nervous System
                                                                                                                                                                                                                                                                                                                              • Plant Hormones
                                                                                                                                                                                                                                                                                                                                • 8.11 Effects of Plant Hormones
                                                                                                                                                                                                                                                                                                                                  • 8.12 Core Practical 18: Amylase in Germinating Cereal Grains
                                                                                                                                                                                                                                                                                                                                    • 8.13 Nervous & Hormonal Coordination
                                                                                                                                                                                                                                                                                                                                    • The Brain
                                                                                                                                                                                                                                                                                                                                      • 8.14 Human Brain Structures & Functions
                                                                                                                                                                                                                                                                                                                                        • 8.15 Techniques to Investigate the Brain
                                                                                                                                                                                                                                                                                                                                          • 8.16 Brain Disease
                                                                                                                                                                                                                                                                                                                                          • Gene Technology
                                                                                                                                                                                                                                                                                                                                            • 8.17 Drug Production from Genetically Modified Organisms
                                                                                                                                                                                                                                                                                                                                              • 8.18 Recombinant DNA
                                                                                                                                                                                                                                                                                                                                                • 8.19 Transfer of Recombinant DNA into Other Cells
                                                                                                                                                                                                                                                                                                                                                  • 8.20 Identification of Active Genes
                                                                                                                                                                                                                                                                                                                                                    • 8.21 Bioinformatics
                                                                                                                                                                                                                                                                                                                                                      • 8.22 Risks & Benefits of Using GMOs


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                                                                                                                                                                                                                                                                                                                                                    Author: Naomi

                                                                                                                                                                                                                                                                                                                                                    Naomi graduated in 2007 from the University of Oxford with a degree in Biological Sciences. She has 8 years of classroom experience teaching Key Stage 3 up to A-Level biology, and is currently a tutor and A-Level examiner. Naomi especially enjoys creating resources that enable students to build a solid understanding of subject content, while also connecting their knowledge with biology’s exciting, real-world applications. Naomi has a little cat called Buzz, and enjoys knitting.


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