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Edexcel International A Level Biology

Revision Notes

Home / International A Level / Biology / Edexcel / Revision Notes / 1. Molecules, Transport & Health / The Circulatory System / 1.6 The Need for a Circulatory System


1.6 The Need for a Circulatory System


The Need for a Circulatory System

  • The cells of all living organisms need a constant supply of reactants for metabolism, e.g. oxygen and glucose
  • Single-celled organisms can gain oxygen and glucose directly from their surroundings and the molecules can diffuse to all parts of the cell quickly due to short diffusion distances
  • Larger organisms, however, are made up of many layers of cells, meaning that the time taken for substances such as glucose and oxygen to diffuse to every cell in the body would be far too long
    • The diffusion distances involved are too great
    • Large organisms often have high energy requirements, so the delivery of reactants for metabolism needs to happen quickly
  • To solve this problem their exchange surfaces are connected to a mass transport system, for example
    • The digestive system is connected to the circulatory system
    • The lungs are connected to the circulatory system
  • Mass transport is the bulk movement of gases or liquids in one direction, usually via a system of vessels and tubes
  • The circulatory system in mammals is a well-studied example of a mass transport system; the one-way flow of blood within the blood vessels carries essential nutrients and gases to all the cells of the body
  • Mass transport systems help to
    • Bring substances quickly from one exchange site to another
    • Maintain diffusion gradients at exchange sites and between cells and their fluid surroundings
    • Ensure effective cell activity by supplying reactants and removing waste products

The double circulatory system in mammals

Mammals have a circulatory system known as a double circulatory system; the blood travels around the body in two separate circuits known as the pulmonary and systemic circulation



  • 1. Molecules, Transport & Health
    • Biological Molecules
      • 1.1 The Importance of Water
        • 1.2 Saccharides
          • 1.3 Core Practical 1: Estimating the Concentration of Sugars & Starch
            • 1.4 Condensation & Hydrolysis
              • 1.5 Triglycerides & Ester Bonds
              • The Circulatory System
                • 1.6 The Need for a Circulatory System
                  • 1.7 Blood Vessels: Structure & Function
                    • 1.8 The Cardiac Cycle
                      • 1.9 The Role of Haemoglobin
                        • 1.10 Atherosclerosis
                          • 1.11 Blood Clotting
                          • Diet & Health
                            • 1.12 Reducing Risk Factors of CVD
                              • 1.13 Dietary Antioxidants & CVD
                                • 1.14 Core Practical 2: Investigate the Vitamin C Content of Food & Drink
                                  • 1.15 Interpreting Data on Risk Factors
                                    • 1.16 Designing Studies into the Effects of Risk Factors
                                      • 1.17 Perception of Risk vs Actual Risk
                                        • 1.18 Data on Cholesterol & Lipoproteins
                                          • 1.19 Data on Effect of Diet
                                            • 1.20 Treatments for CVD: Benefits & Risks
                                          • 2. Membranes, Proteins, DNA & Gene Expression
                                            • Gas Exchange, Cell Membranes & Transport
                                              • 2.1 Properties of Gas Exchange Surfaces
                                                • 2.2 Cell Membranes
                                                  • 2.3 Core Practical 3: Investigating Membrane Structure & Permeability
                                                    • 2.4 Osmosis
                                                      • 2.5 Diffusion, Facilitated Diffusion & Active Transport
                                                      • Proteins
                                                        • 2.6 Amino Acids, Proteins & Protein Structure
                                                          • 2.7 Enzymes: Roles & Modes of Action
                                                            • 2.8 Core Practical 4: Investigating the Rate of Enzyme Reactions
                                                              • 2.9 Nucleotides, DNA & RNA, Base Pairing
                                                              • DNA & Gene Expression
                                                                • 2.10 DNA Replication
                                                                  • 2.11 The Nature of the Genetic Code
                                                                    • 2.12 How Bases Code for a Polypeptide Chain
                                                                      • 2.13 Transcription & Translation
                                                                      • Inheritance
                                                                        • 2.14 Mutations
                                                                          • 2.15 Patterns of Inheritance & Sex Linkage
                                                                            • 2.16 Cystic Fibrosis
                                                                              • 2.17 Genetic Screening
                                                                                • 2.18 Ethical & Social Issues of Genetic Screening
                                                                              • 3. Cell Structure, Reproduction & Development
                                                                                • Cell Structure & Organisation
                                                                                  • 3.1 Cell Theory
                                                                                    • 3.2 Levels of Organisation of Cells
                                                                                      • 3.3 Eukaryotic Cells
                                                                                        • 3.4 The Rough Endoplasmic Reticulum & Golgi
                                                                                          • 3.5 Prokaryotic Cells
                                                                                            • 3.6 Electron Microscopy of Animal Cells
                                                                                              • 3.7 Microscopy: Magnification & Resolution
                                                                                                • 3.8 Core Practical 5: Light Microscopy
                                                                                                • Reproduction & Inheritance
                                                                                                  • 3.9 Gene Locus
                                                                                                    • 3.10 Meiosis & Variation
                                                                                                      • 3.11 Mammalian Gametes
                                                                                                        • 3.12 Fertilisation: Mammals
                                                                                                          • 3.13 Fertilisation: Flowering Plants
                                                                                                            • 3.14 The Cell Cycle & Mitosis
                                                                                                              • 3.15 Core Practical 6: Observing the Stages of Mitosis
                                                                                                                • 3.16 Calculation of Mitotic Index
                                                                                                                  • 3.17 Stem Cells & Cell Potency
                                                                                                                    • 3.18 Cell Specialisation
                                                                                                                      • 3.19 Post-Transcriptional Changes to mRNA
                                                                                                                        • 3.20 Gene Interaction & Epigenetics
                                                                                                                          • 3.21 Polygenic Inheritance & Continuous Variation
                                                                                                                        • 4. Plant Structure & Function, Biodiversity & Conservation
                                                                                                                          • Plant Structure & Function
                                                                                                                            • 4.1 Plant Cell Structure
                                                                                                                              • 4.2 Electron Microscopy of Plant Cells
                                                                                                                                • 4.3 Starch & Cellulose: Structure & Function
                                                                                                                                  • 4.4 Properties of Cellulose
                                                                                                                                    • 4.5 The Vascular Structure of Plants
                                                                                                                                      • 4.6 Core Practical 7: Identifying Tissue Types Within Stems
                                                                                                                                      • Plants & Conservation
                                                                                                                                        • 4.7 Plant-Based Products for Sustainability
                                                                                                                                          • 4.8 Water & Inorganic Ions in Plants
                                                                                                                                            • 4.9 Core Practical 8: Determining the Tensile Strength of Plant Fibres
                                                                                                                                            • Plants & Bacterial Growth
                                                                                                                                              • 4.10 Bacterial Growth Conditions
                                                                                                                                                • 4.11 Plant Products with Antimicrobial Properties
                                                                                                                                                  • 4.12 Core Practical 9: Antimicrobial Properties of Plants
                                                                                                                                                    • 4.13 Development of Drugs & Drug Testing
                                                                                                                                                    • Classification & Biodiversity
                                                                                                                                                      • 4.14 The Three Domains of Life
                                                                                                                                                        • 4.15 The Variety of Life
                                                                                                                                                          • 4.16 Biodiversity & Endemism
                                                                                                                                                            • 4.17 Species Richness & Heterozygosity Index
                                                                                                                                                              • 4.18 Index of Biodiversity
                                                                                                                                                                • 4.19 Ecological Niches & Adaptations
                                                                                                                                                                  • 4.20 Hardy-Weinberg Equation
                                                                                                                                                                    • 4.21 Roles of Seed Banks & Zoos in Conservation
                                                                                                                                                                  • 5. Energy Flow, Ecosystems & the Environment
                                                                                                                                                                    • Photosynthesis
                                                                                                                                                                      • 5.1 Photosynthesis: Overview
                                                                                                                                                                        • 5.2 The Role of ATP in Photosynthesis
                                                                                                                                                                          • 5.3 Photosynthesis: Light-Dependent Stage
                                                                                                                                                                            • 5.4 Photosynthesis: Light-Independent Stage
                                                                                                                                                                              • 5.5 Chloroplasts
                                                                                                                                                                                • 5.6 Absorption & Action Spectra
                                                                                                                                                                                  • 5.7 Separation of Photosynthetic Pigments with Chromatography
                                                                                                                                                                                    • 5.8 Core Practical 10: Rate of Photosynthesis
                                                                                                                                                                                    • Ecosystems
                                                                                                                                                                                      • 5.9 Ecological Productivity
                                                                                                                                                                                        • 5.10 Energy & Biomass Transfers
                                                                                                                                                                                          • 5.11 Ecology: Key Terms
                                                                                                                                                                                            • 5.12 Factors Affecting Populations
                                                                                                                                                                                              • 5.13 Niche
                                                                                                                                                                                                • 5.14 Core Practical 11: Quadrat & Transect Study
                                                                                                                                                                                                  • 5.15 Ecological Succession
                                                                                                                                                                                                  • Environmental Biology
                                                                                                                                                                                                    • 5.16 Evidence for Climate Change
                                                                                                                                                                                                      • 5.17 Anthropogenic Climate Change
                                                                                                                                                                                                        • 5.18 Carbon Cycle & Environmental Management
                                                                                                                                                                                                          • 5.19 Models for Predicting Climate Change
                                                                                                                                                                                                            • 5.20 How Climate Change Affects Species
                                                                                                                                                                                                              • 5.21 The Effect of Temperature on Enzyme Reactions
                                                                                                                                                                                                                • 5.22 Core Practical 12: Effect of Temperature on Development
                                                                                                                                                                                                                  • 5.23 Mutation, Natural Selection & Evolution
                                                                                                                                                                                                                    • 5.24 Isolation & Speciation
                                                                                                                                                                                                                      • 5.25 Contentious Issues in Environmental Science
                                                                                                                                                                                                                        • 5.26 Examples of Sustainable Conservation
                                                                                                                                                                                                                      • 6. Microbiology, Immunity & Forensics
                                                                                                                                                                                                                        • Microbiology
                                                                                                                                                                                                                          • 6.1 Culturing Microorganisms
                                                                                                                                                                                                                            • 6.2 Measuring the Growth of Microorganisms
                                                                                                                                                                                                                              • 6.3 The Bacterial Growth Curve
                                                                                                                                                                                                                                • 6.4 Core Practical 13: Rate of Growth of Microorganisms
                                                                                                                                                                                                                                  • 6.5 Comparison of Bacterial & Viral Structure
                                                                                                                                                                                                                                  • Immunity
                                                                                                                                                                                                                                    • 6.6 Tuberculosis & HIV
                                                                                                                                                                                                                                      • 6.7 Pathogens: Routes of Entry
                                                                                                                                                                                                                                        • 6.8 Non-Specific Immune Responses
                                                                                                                                                                                                                                          • 6.9 Specific Immune Responses
                                                                                                                                                                                                                                            • 6.11 Developing Immunity
                                                                                                                                                                                                                                              • 6.12 Pathogens vs Hosts: An Evolutionary Race
                                                                                                                                                                                                                                              • Antibiotics
                                                                                                                                                                                                                                                • 6.13 Antibiotics
                                                                                                                                                                                                                                                  • 6.14 Core Practical 14: The Effects of Different Antibiotics
                                                                                                                                                                                                                                                    • 6.15 Current Usage of Antibiotics
                                                                                                                                                                                                                                                    • Decomposition & Decay
                                                                                                                                                                                                                                                      • 6.16 The Role of Microorganisms
                                                                                                                                                                                                                                                      • Forensics
                                                                                                                                                                                                                                                        • 6.17 Polymerase Chain Reaction
                                                                                                                                                                                                                                                          • 6.18 Gel Electrophoresis in Forensics
                                                                                                                                                                                                                                                            • 6.19 DNA Profiling
                                                                                                                                                                                                                                                              • 6.20 Types of Data Provided by Forensic Analysis
                                                                                                                                                                                                                                                            • 7. Respiration, Muscles & the Internal Environment
                                                                                                                                                                                                                                                              • Respiration
                                                                                                                                                                                                                                                                • 7.1 Overview of Respiration
                                                                                                                                                                                                                                                                  • 7.2 Glycolysis
                                                                                                                                                                                                                                                                    • 7.3 Link Reaction & Krebs Cycle
                                                                                                                                                                                                                                                                      • 7.4 The Electron Transport Chain
                                                                                                                                                                                                                                                                        • 7.5 Anaerobic Respiration
                                                                                                                                                                                                                                                                          • 7.6 Respiratory Quotient
                                                                                                                                                                                                                                                                            • 7.7 Core Practical 15: Investigation of Respiration in Yeast
                                                                                                                                                                                                                                                                              • 7.8 Core Practical 16: Respirometer to Calculate RQ
                                                                                                                                                                                                                                                                              • Muscular Movement
                                                                                                                                                                                                                                                                                • 7.9 The Musculoskeletal System
                                                                                                                                                                                                                                                                                  • 7.10 The Muscle Fibre
                                                                                                                                                                                                                                                                                    • 7.11 The Process of Skeletal Muscle Contraction
                                                                                                                                                                                                                                                                                      • 7.12 The Role of Muscle in the Cardiac Cycle
                                                                                                                                                                                                                                                                                        • 7.13 Calculation of Cardiac Output
                                                                                                                                                                                                                                                                                          • 7.14 The Role of Adrenaline
                                                                                                                                                                                                                                                                                            • 7.15 Core Practical 17: The Effects of Exercise
                                                                                                                                                                                                                                                                                            • The Internal Environment
                                                                                                                                                                                                                                                                                              • 7.16 Negative & Positive Feedback
                                                                                                                                                                                                                                                                                                • 7.17 Homeostasis
                                                                                                                                                                                                                                                                                                  • 7.18 The Kidney: Structure
                                                                                                                                                                                                                                                                                                    • 7.19 Urea as a Waste Product
                                                                                                                                                                                                                                                                                                      • 7.20 Selective Reabsorption in the Kidney
                                                                                                                                                                                                                                                                                                        • 7.21 Hormones in Osmoregulation
                                                                                                                                                                                                                                                                                                          • 7.22 Control of Gene Expression
                                                                                                                                                                                                                                                                                                        • 8. Coordination, Response & Gene Technology
                                                                                                                                                                                                                                                                                                          • The Nervous System
                                                                                                                                                                                                                                                                                                            • 8.1 Neurones: Types and Functions
                                                                                                                                                                                                                                                                                                              • 8.2 How a Response is Generated by Effectors
                                                                                                                                                                                                                                                                                                                • 8.3 The Reflex Arc
                                                                                                                                                                                                                                                                                                                  • 8.4 The Nerve Impulse
                                                                                                                                                                                                                                                                                                                    • 8.5 Myelination & Saltatory Conduction
                                                                                                                                                                                                                                                                                                                      • 8.6 Synapses & Neurotransmitters
                                                                                                                                                                                                                                                                                                                        • 8.7 The Effects of Drugs on Nervous Transmission
                                                                                                                                                                                                                                                                                                                          • 8.8 Detection of Stimuli
                                                                                                                                                                                                                                                                                                                            • 8.9 Habituation
                                                                                                                                                                                                                                                                                                                              • 8.10 Central & Peripheral Nervous System
                                                                                                                                                                                                                                                                                                                              • Plant Hormones
                                                                                                                                                                                                                                                                                                                                • 8.11 Effects of Plant Hormones
                                                                                                                                                                                                                                                                                                                                  • 8.12 Core Practical 18: Amylase in Germinating Cereal Grains
                                                                                                                                                                                                                                                                                                                                    • 8.13 Nervous & Hormonal Coordination
                                                                                                                                                                                                                                                                                                                                    • The Brain
                                                                                                                                                                                                                                                                                                                                      • 8.14 Human Brain Structures & Functions
                                                                                                                                                                                                                                                                                                                                        • 8.15 Techniques to Investigate the Brain
                                                                                                                                                                                                                                                                                                                                          • 8.16 Brain Disease
                                                                                                                                                                                                                                                                                                                                          • Gene Technology
                                                                                                                                                                                                                                                                                                                                            • 8.17 Drug Production from Genetically Modified Organisms
                                                                                                                                                                                                                                                                                                                                              • 8.18 Recombinant DNA
                                                                                                                                                                                                                                                                                                                                                • 8.19 Transfer of Recombinant DNA into Other Cells
                                                                                                                                                                                                                                                                                                                                                  • 8.20 Identification of Active Genes
                                                                                                                                                                                                                                                                                                                                                    • 8.21 Bioinformatics
                                                                                                                                                                                                                                                                                                                                                      • 8.22 Risks & Benefits of Using GMOs


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                                                                                                                                                                                                                                                                                                                                                    Author: Naomi

                                                                                                                                                                                                                                                                                                                                                    Naomi graduated in 2007 from the University of Oxford with a degree in Biological Sciences. She has 8 years of classroom experience teaching Key Stage 3 up to A-Level biology, and is currently a tutor and A-Level examiner. Naomi especially enjoys creating resources that enable students to build a solid understanding of subject content, while also connecting their knowledge with biology’s exciting, real-world applications. Naomi has a little cat called Buzz, and enjoys knitting.


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