Neural Signalling (SL IB Biology)

Serotonin is a neurotransmitter found in the brain. Low serotonin levels are thought to contribute to symptoms of clinical depression. One commonly used treatment for depression involves a group of drugs called SSRIs.

The diagram below shows a serotonin synapse in the brain both before (left) and after (right) treatment with SSRIs.

Suggest how SSRIs might be effective at treating the symptoms of depression.

The image below shows the chemical structures of serotonin and an SSRI called Citalopram. Citalopram is commonly prescribed for depression due to its limited side effects, but it does sometimes cause some nausea and sleep disturbance during the first few weeks.

Use the image to suggest how Citalopram can have the effect shown in part a) while also having some side effects.

Although the use of SSRIs has increased significantly in recent years there is still controversy over their effectiveness in the treatment of depression, along with some concern surrounding withdrawal symptoms at the end of treatment. One group of researchers analysed the results of around 300 studies involving treatment for depression; some of their results are shown in the graph below.

The placebo in this case was a pill identical in appearance to an SSRI but containing no active chemical ingredients.

Suggest the role of a placebo in a study of this type.

State what can be concluded about the effectiveness of SSRIs in the treatment of depression from the information provided in part c). Note that the error bars in the graph represent standard deviation.

Describe how a nerve impulse is transmitted from one neurone to another.

Body temperature can affect the speed of an action potential. Research has found that reaction time is slower when body temperature falls. This is because nerve impulse conduction is slower.

Explain how a lower temperature leads to slower nerve impulse conduction.

After exercise, ATP is required for the resting potential to be re-established in axons. Explain how this occurs.

Below is a micrograph of a synapse. The arrow shows the direction of the nerve impulse.

Label on the diagram the synaptic vesicles and the synaptic cleft.

Dopamine is a neurotransmitter that plays a vital role in areas of the brain responsible for muscle control. It is transported back out of the synaptic cleft by a transporter protein located within the presynaptic membrane. Dopamine diffuses across the synaptic gap and binds to a receptor on the postsynaptic membrane.

Describe how this results in the depolarisation of the postsynaptic membrane.

Explain why it is essential that neurotransmitters like dopamine are transported back out of synapses.

Describe the mechanism which allows information to pass across a synapse.