CIE A Level Biology (9700) 2019-2021

Revision Notes

8.1.5 Blood, Tissue Fluid & Lymph

Blood, Tissue Fluid & Lymph

  • Plasma is a straw-coloured liquid that constitutes around 55% of the blood
  • Plasma is largely composed of water (95%) and because water is a good solvent, many substances can dissolve in it, allowing them to be transported around the body
  • As blood passes through capillaries, some plasma leaks out through gaps in the walls of the capillary to surround the cells of the body
    • This results in the formation of tissue fluid
  • The composition of plasma and tissue fluid are virtually the same, although tissue fluid contains far fewer proteins
    • Proteins are too large to fit through gaps in the capillary walls and so remain in the blood
  • Tissue fluid bathes almost all the cells of the body outside of the circulatory system
  • Exchange of substances between cells and the blood occurs via the tissue fluid
    • For example, carbon dioxide produced in aerobic respiration will leave a cell, dissolve into the tissue fluid surrounding it, and then diffuse into the capillary

Tissue fluid formation

  • How much liquid leaves the plasma to form tissue fluid depends on two opposing forces
  • When blood is at the arteriole end of a capillary, the hydrostatic pressure is great enough to push molecules out of the capillary
  • Proteins remain in the blood; the increased protein content creates a water potential between the capillary and the tissue fluid
    • However, overall movement of water is out from the capillaries into the tissue fluid
  • At the venule end of the capillary, less fluid is pushed out of the capillary as pressure within the capillary is reduced
  • The water potential gradient between the capillary and the tissue fluid remains the same as at the arteriole end, so water begins to flow back into the capillary from the tissue fluid
  • Overall, more fluid leaves the capillary than returns, leaving tissue fluid behind to bathe cells
  • If blood pressure is high (hypertension) then the pressure at the arteriole end is even greater
    • This pushes more fluid out of the capillary and fluid begins to accumulate around the tissues. This is called oedema

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