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OCR Gateway GCSE Biology

Revision Notes

Home / GCSE / Biology / OCR Gateway / Revision Notes / 6. Global Challenges / 6.3 Monitoring & Maintaining Health / 6.3.1 Health & Disease: Disease Types


6.3.1 Health & Disease: Disease Types


Communicable & Non-Communicable Disease

Defining health

  • The World Health Organisation (WHO) defines health as 'a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity'
  • This means that health is not just dependent on whether an individual is physically sick or not.
  • There are lots of factors that should be considered when assessing the health of an individual which includes mental health as well as the level of social support in place

Communicable diseases

  • Communicable diseases are caused by microorganisms called pathogens which can spread between individuals
    • E.g. chickenpox, a common childhood disease, is caused by a viral pathogen called the varicella-zoster virus

Communicable Diseases Table

Table of Common Pathogens & Communicable Diseases in Humans, downloadable AS & A Level Biology revision notes

Non-communicable diseases

  • Non-communicable diseases are not caused by pathogens and cannot be passed on between individuals
    • Their effects on health tend to be longer-lasting
    • Examples include: asthma, CHD and most cancers
  • The risk of developing non-communicable diseases may be increased by certain factors (including diet, stress and life situations) as these factors may have a profound effect on both physical and mental health
    • Eating a balanced diet that provides the right amount of energy and nutrients helps maintain good health whereas a poor diet can lead to deficiencies, obesity, diabetes and poor mental health
    • Constantly being under stress can lead to cardiovascular issues (such as high blood pressure, increasing the risk of CHD) and poor mental health
    • Where a person lives and their income can have a profound impact on health - this affects the standard of healthcare that is accessible to them (and what they can afford), what food they buy etc.

Risk Factors in Non-Communicable Diseases Table

Lifestyle & Non-Communicable Diseases (1), downloadable IGCSE & GCSE Biology revision notes

Exam Tip

Not ALL microorganisms are harmful! In fact, the vast majority are either beneficial to humans or do no harm.

Always remember, mental health is as important as physical health.

Think of communicable diseases as those which are caught!

Cancer is not a genetic disease, but some individuals may have a genetic predisposition that increases their likelihood of developing specific cancers.

Interactions Between Diseases

Susceptibility

  • If an individual suffers from one disease, they are likely to be more susceptible to other diseases
  • This is because the immune system may be compromised in some way or the different types of disease may interact in ways that affect the health of the individual negatively 
    • Defects in the immune system mean that an individual is more likely to suffer from infectious diseases
      • Individuals infected with HIV eventually end up with reduced numbers of lymphocytes (a type of white blood cell) circulating around the blood
      • This reduces the ability of the immune system to tackle opportunistic infections like pneumonia
  •  Viruses living in cells can be the trigger for cancers; the HPV virus can infect cells of the cervix in women resulting in cervical cancer developing in some cases, whereas some strains of the hepatitis virus can cause liver cancer
  • Immune reactions initially caused by a pathogen can trigger allergies such as skin rashes and asthma - these often develop as a result of an overactive immune response
  • Severe physical ill health can lead to depression and other mental illness; both can impact the immune system negatively and affect lifestyle choices made by the individual, further compounding the effects of poor health

The interaction of HIV and AIDS

  • Human Immunodeficiency Virus (HIV) destroys white blood cells in the immune system
  • Initial symptoms are flu-like
    • This includes headaches, high temperature, joint and muscle pains
  • If untreated, the virus compromises the immune system leading to the onset of Acquired Immune Deficiency Syndrome (AIDS)
  • AIDS is used to refer to several life-threatening illnesses which may result from having a compromised immune system
    • The most common of these is pneumonia
  • The virus infects a certain type of lymphocyte of the immune system
  • Normally lymphocytes seek out and destroy pathogens that enter the body, producing antibodies that attach to pathogens, enhancing phagocytic activity
  • However, HIV avoids being recognised and destroyed by lymphocytes by repeatedly changing its protein coat
  • It then infects a certain type of lymphocyte and uses the cells’ machinery to multiply
  • This reduces the number of lymphocytes of the immune system
    • And therefore the number of antibodies that can be made
  • As a result, the body has a reduced ability to tackle infections, eventually leading to AIDS (Acquired immunodeficiency)

How HIV affects lymphocytes, IGCSE & GCSE Biology revision notes

How HIV affects lymphocytes

The interaction of HPV and cervical cancer

  • Human Papilloma Virus (HPV) can be associated with cervical cancer
    • HPV is sexually transmitted, though is not thought to affect men, who are carriers of the virus
  • HPV viruses living in cells can be the trigger for cervical cancer in women
  • Girls aged 12-13 are injected with a vaccine for HPV
    • Before they reach the age of sexual activity
  • Vaccination triggers an immune response
    • Which reduces the risk of viruses spreading in a subsequent infection
  • So in turn, the risk of cervical cancer in those girls/women is reduced

Exam Tip

When associating disease with another factor, it is always helpful to write in terms of the level of risk.

So, rather than saying, "HPV causes cervical cancer", a more accurate statement would be, "HPV increases the risk of (a woman) developing cervical cancer".



  • 1. Cell Level Systems
    • 1.1 Cell Structures
      • 1.1.1 Light Microscopes
        • 1.1.2 Cell Structure
          • 1.1.3 Electron Microscopes
          • 1.2 What Happens in Cells (& What do Cells Need?)
            • 1.2.1 DNA Structure
              • 1.2.2 Nucleotides
                • 1.2.3 Protein Synthesis
                  • 1.2.4 The Mechanism of Enzyme Action
                  • 1.3 Respiration
                    • 1.3.1 Respiration is a Chemical Process
                      • 1.3.2 Aerobic & Anaerobic Respiration
                        • 1.3.3 Biological Molecules
                          • 1.3.4 Tests for Biological Molecules
                          • 1.4 Photosynthesis
                            • 1.4.1 Photosynthetic Organisms as Producers
                              • 1.4.2 The Effect of 3 Factors on Photosynthesis
                                • 1.4.3 Limiting Factors - Photosynthesis
                              • 2. Scaling Up
                                • 2.1 Supplying the Cell
                                  • 2.1.1 Cellular Transport - Diffusion & Osmosis
                                    • 2.1.2 Cellular Transport - Active Transport
                                      • 2.1.3 Mitosis & the Cell Cycle
                                        • 2.1.4 Cell Differentiation
                                          • 2.1.5 Stem Cells in Animals & Plants
                                            • 2.1.6 Embryonic & Adult Stem Cells in Animals
                                            • 2.2 The Challenges of Size
                                              • 2.2.1 Surface Area: Volume Ratio & Transport
                                                • 2.2.2 Transport Into & Out of Organisms
                                                  • 2.2.3 The Heart
                                                    • 2.2.4 Blood Vessels
                                                      • 2.2.5 Blood Composition
                                                        • 2.2.6 Transport of Water & Mineral Ions in Plants
                                                          • 2.2.7 Transpiration & Translocation
                                                            • 2.2.8 Xylem & Phloem
                                                              • 2.2.9 Affecting Water Uptake by a Plant
                                                            • 3. Organism Level Systems
                                                              • 3.1 Coordination & Control – the Nervous System
                                                                • 3.1.1 The Nervous System - Structure
                                                                  • 3.1.2 Generating a Nervous Response
                                                                    • 3.1.3 The Reflex Arc
                                                                      • 3.1.4 The Eye
                                                                        • 3.1.5 The Brain
                                                                          • 3.1.6 Investigating Brain Function
                                                                          • 3.2 Coordination & Control – the Endocrine System
                                                                            • 3.2.1 Hormonal Control
                                                                              • 3.2.2 Thyroxine & Adrenaline
                                                                                • 3.2.3 Hormones in Human Reproduction
                                                                                  • 3.2.4 Four Hormones in the Menstrual Cycle
                                                                                    • 3.2.5 Contraception
                                                                                      • 3.2.6 Hormones to Treat Infertility
                                                                                        • 3.2.7 Plant Hormones - Tropisms
                                                                                          • 3.2.8 Use of Plant Hormones by Humans
                                                                                          • 3.3 Maintaining Internal Environments
                                                                                            • 3.3.1 Constant Internal Environment
                                                                                              • 3.3.2 The Skin in Temperature Control
                                                                                                • 3.3.3 Insulin in Blood Sugar Control
                                                                                                  • 3.3.4 Glucagon in Blood Sugar Control
                                                                                                    • 3.3.5 Osmotic Changes in Body Fluids
                                                                                                      • 3.3.6 The Kidneys
                                                                                                        • 3.3.7 ADH in Water Reabsorption
                                                                                                          • 3.3.8 Responses to Extremes
                                                                                                        • 4. Community Level Systems
                                                                                                          • 4.1 Ecosystems
                                                                                                            • 4.1.1 The Cycling of Materials
                                                                                                              • 4.1.2 The Carbon Cycle
                                                                                                                • 4.1.3 Decomposition & Decay
                                                                                                                  • 4.1.4 Levels of Organisation in an Ecosystem
                                                                                                                    • 4.1.5 Abiotic & Biotic Factors
                                                                                                                      • 4.1.6 Interdependence & Competition
                                                                                                                        • 4.1.7 Trophic Levels of Organisms
                                                                                                                          • 4.1.8 Pyramids of Biomass & Biomass Transfers
                                                                                                                        • 5. Genes, Inheritance & Selection
                                                                                                                          • 5.1 Inheritance
                                                                                                                            • 5.1.1 The Genome & Genetics
                                                                                                                              • 5.1.2 Variation
                                                                                                                                • 5.1.3 Influence of Genetic Variants on Phenotype
                                                                                                                                  • 5.1.4 Sexual Reproduction
                                                                                                                                    • 5.1.5 Asexual Reproduction
                                                                                                                                      • 5.1.6 Inheritance
                                                                                                                                        • 5.1.7 The History of Genetics
                                                                                                                                        • 5.2 Natural Selection & Evolution
                                                                                                                                          • 5.2.1 Genetic Variation Within a Population
                                                                                                                                            • 5.2.2 Evolution Through Natural Selection
                                                                                                                                              • 5.2.3 Classification
                                                                                                                                            • 6. Global Challenges
                                                                                                                                              • 6.1 Monitoring & Maintaining the Environment
                                                                                                                                                • 6.1.1 The Distribution & Abundance of Organisms
                                                                                                                                                  • 6.1.2 Human Interactions Within Ecosystems
                                                                                                                                                    • 6.1.3 Maintaining Biodiversity
                                                                                                                                                      • 6.1.4 The Impact of Environmental Changes
                                                                                                                                                      • 6.2 Feeding the Human Race
                                                                                                                                                        • 6.2.1 Food Security
                                                                                                                                                          • 6.2.2 Selective Breeding of Food Products
                                                                                                                                                            • 6.2.3 Genetic Engineering
                                                                                                                                                              • 6.2.4 The Process of Genetic Engineering
                                                                                                                                                                • 6.2.5 Biotechnology & Human Population
                                                                                                                                                                • 6.3 Monitoring & Maintaining Health
                                                                                                                                                                  • 6.3.1 Health & Disease: Disease Types
                                                                                                                                                                    • 6.3.2 Communicable Diseases
                                                                                                                                                                      • 6.3.3 Plant Disease - Detection & Identification
                                                                                                                                                                        • 6.3.4 White Blood Cells & Platelets
                                                                                                                                                                          • 6.3.5 Non-Specific Defences
                                                                                                                                                                            • 6.3.6 The Human Immune System
                                                                                                                                                                              • 6.3.7 Monoclonal Antibodies
                                                                                                                                                                                • 6.3.8 Vaccines Against Disease
                                                                                                                                                                                  • 6.3.9 Developing New Medicines
                                                                                                                                                                                    • 6.3.10 Non-Communicable Human Diseases
                                                                                                                                                                                      • 6.3.11 Stem Cells in Medicine
                                                                                                                                                                                        • 6.3.12 Gene Technology in Medicine
                                                                                                                                                                                      • 7. Practical Skills
                                                                                                                                                                                        • 7.1 Practical Skills
                                                                                                                                                                                          • 7.1.1 Practical - Using Light Microscopes to View Cells
                                                                                                                                                                                            • 7.1.2 Practical - Testing for Food Molecules
                                                                                                                                                                                              • 7.1.3 Practical - DNA Extraction
                                                                                                                                                                                                • 7.1.4 Practical - Sampling Techniques - Quadrats
                                                                                                                                                                                                  • 7.1.5 Practical - Investigating Enzymatic Reactions
                                                                                                                                                                                                    • 7.1.6 Practical - Investigating Photosynthesis
                                                                                                                                                                                                      • 7.1.7 Practical - Investigating Respiration
                                                                                                                                                                                                        • 7.1.8 Practical - Using a Potometer
                                                                                                                                                                                                          • 7.1.9 Practical - Measurement of Stomatal Density
                                                                                                                                                                                                            • 7.1.10 Practical - Aseptic Technique
                                                                                                                                                                                                              • 7.1.11 Practical - Surface Area: Volume Ratio
                                                                                                                                                                                                                • 7.1.12 Practical - Investigating Osmosis


                                                                                                                                                                                                                DOWNLOAD PDF

                                                                                                                                                                                                              Author: Phil

                                                                                                                                                                                                              Phil graduated in Biochemistry from Birmingham University and spent seventeen years in the drinks and chemicals industries. He holds an MBA from Manchester Business School. More recently, Phil has taught in secondary schools, examined GCSE Biology and has also co-directed a tuition agency. He is a passionate believer in promoting numeracy in his teaching and loves to create innovative resources. Away from work, Phil loves to be outside, cycling, running or hiking; when relaxing indoors, he plays classical guitar.


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