Edexcel GCSE Biology

Topic Questions

8.4 Circulatory System

1a
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3 marks

The function of red blood cells is to transport oxygen around the body in the blood. 

Explain how the shape of a red blood cell is related to its function. 

1b
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2 marks

As well as its shape, the red blood cell also has internal adaptations to allow it to carry out its function. 

One of these is that it doesn't have a nucleus. 

Explain why this is beneficial for the functioning of the cell. 

1c
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2 marks

Table 1 shows the number of blood cells per dm3 of blood of two people.

 Table 1

Type of blood cell Number of cells per dmof blood
Person A Person B
Red blood cell 5 x 1012 6 x 1012
White blood cell 9 x 109 7 x 1010

Give the number of white blood cells per dm3 of blood for person A and person B as a normal number. 

1d
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4 marks

Of the two people in Table 1, one of them is infected with a pathogen.

Identify the infected person and give a reason for your answer. 

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2a
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2 marks

Figure 1 shows a diagram of the heart. 

2NRtXWiz_4

Figure 1

Explain the difference in thickness of the walls of chamber A and chamber B.

2b
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2 marks

The heart contains valves that can sometimes experience faults.

Describe what would happen to the blood flow in the heart if one of the valves did not function effectively.

2c
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6 marks

Blood from the body enters the heart through the vena cava.

Using Figure 1 and your own knowledge, describe how this blood flows through the heart and lungs to leave the heart through the aorta.

Include references to the chambers of the heart and the relevant valves in your answer.

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3a
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2 marks

Figure 1 compares the structure of two main blood vessels in the body.

6-2-easy-q2a

Figure 1

(i)

Identify blood vessel A.

(1)

(ii)

State a reason for your answer in part (i).

(1)

3b
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2 marks

Blood vessel B has a very large lumen.

(i)

Identify blood vessel B.

(1)

(ii)

State one reason for the presence of a large lumen in blood vessel B.

(1)

3c
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2 marks

The flow of blood in veins is not assisted by the pressure generated by the beating of the heart.

List two structures that assist with the flow of blood in veins.

3d
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2 marks

Figure 2 shows part of the blood circulation of a mammal.

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Figure 2

(i)

Identify one label from Figure 2 which is an example of a blood vessel A from Figure 1

(1)

(ii)

Identify one label from Figure 2 which is an example of a blood vessel B from Figure 1

(1)

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1a
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7 marks

Figure 1 shows a cross-section of the three different types of blood vessel. 

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Figure 1

Complete the table below by putting a tick () in the correct boxes for each type of vessel shown in Figure 1

blood-vessels-table

1b
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4 marks

The elasticity of blood vessels can be measured using the equipment in Figure 2.

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Figure 2

A student set up the equipment in order to compare the elasticity of arteries and veins. 

(i)
Describe the method that the student could use in order to see how much the ring of tissue from an artery could stretch in comparison to that of a vein. 

(3)

(ii)
Give one safety precaution the student must carry out when handling animal tissue such as blood vessels.

(1)

1c
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3 marks

The student found that the artery tissue could stretch significantly more than the vein. 

Explain why this is an important feature for this type of blood vessel. 

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2a
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3 marks

The function of red blood cells is to transport oxygen around the body in the blood. 

Explain how the shape of a red blood cell is related to its function. 

2b
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2 marks

As well as its shape, the red blood cell also has internal adaptations to allow it to carry out its function. 

One of these is that it doesn't have a nucleus. 

Explain why this is beneficial for the functioning of the cell. 

2c
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2 marks

Figure 1 shows the number of blood cells per dm3 of blood of two people.

number-of-blood-cells-table

Figure 1

Calculate the difference in the number of white blood cells per dm3 of blood between person A and person B. 

2d
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4 marks

Of the two people in Figure 1, one of them is infected with a pathogen.

Identify the infected person and give a reason for your answer. 

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3a
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2 marks

Figure 1 shows a diagram of the heart. 

2NRtXWiz_4

Figure 1

Compare the thickness of the walls of chamber A and chamber B.

3b
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2 marks

The heart contains valves that can sometimes experience faults.

Describe what would happen to the blood flow in the heart if one of the valves did not function effectively.

3c
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6 marks

Blood from the body enters the heart through the vena cava.

Describe how this blood flows through the heart and lungs to leave the heart through the aorta.

Include references to the chambers of the heart and the relevant valves in your answer.

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4a
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2 marks

Name the part of the blood that carries out clotting and state one advantage to this process. 

4b
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2 marks

A student wanted to work out how long it takes blood to clot at different temperatures. 

They repeated their experiment three times and calculated an mean. 

Figure 1 shows the results of their investigation. 

blood-clot-temperature-results

Figure 1

Calculate the mean time taken for blood to clot when the temperature was 35°C. 

4c
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3 marks

Using your answer to part (b), draw a graph to show the data in Figure 1

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4d
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2 marks

Using your answer to part (c), describe the relationship between temperature and the time time taken for the blood to clot.

4e
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2 marks

Give two safety precautions that the student should use when handling blood samples. 

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5a
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2 marks

Figure 1 shows the stroke volume at different heart rates of a person with a high level of fitness and of a person with a low level of fitness.

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Figure 1

Using Figure 1, compare the effect of heart rate on stroke volume of the fit person with the unfit person. 

5b
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3 marks

Calculate the cardiac output for the fit person when the heart rate is 140 beats per minute.

Give the units in your answer.

5c
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3 marks

Explain why it is beneficial for the fit person to have a high stroke volume whilst exercising. 

5d
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1 mark

Suggest a reason for the difference in stroke volume between the fit person and the unfit person.

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6a
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5 marks

Figure 1 shows a diagram of a red blood cell from a turtle and a diagram of a red blood cell from a human.fig-19-1bio-2f-june18-qp-gcse-bio

Figure 1
(i)
These cells are animal cells.

Animal cells do not have

(1)

  A cytoplasm
  B a cell membrane
  C a cell wall
  D mitochondria

(ii)

The actual length of the red blood cell from a turtle is 20.5 μm.

Calculate the length of the magnified image of the red blood cell of the turtle when magnified 400 ×.

(2)

...............................μm

(iii)
The width of the human red blood cell, when magnified 400 ×, is 3.08 mm.

Calculate the actual width of the cell and show your answer in standard form.
(2)

.................................mm

6b
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4 marks

Red blood cells are carried in veins and arteries.

Figure 2 shows the equipment used to measure the elasticity of an artery.fig-20-1bio-2f-june18-qp-gcse-bio

Figure 2

(i)
Describe a method you could use to see how much the ring of tissue from an artery could stretch before it no longer returned to its original size.

(3)

(ii)
Give one safety precaution you need to take when handling animal tissue such as blood vessels.
(1)
6c
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3 marks

Figure 3 shows the circulatory system of a frog.fig-21-1bio-2f-june18-qp-gcse-bio

Figure 3

Explain why the circulatory system of a frog is less efficient at carrying oxygen to the tissues than the circulatory system of a human.

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7a3 marks

Figure 1 shows the estimated blood flow through some parts of the body when a person is at rest and during exercise.

part of the body

estimated rate of blood flow in cm3 per minute

at rest during exercise
brain 750 748
heart muscle 350 1 150
digestive system 2 500 1 200
other muscles 1 200 14 500
all other organs (except lungs) 1 423 1 420

Figure 1

Compare the rate of blood flow through the body when this person is at rest and during exercise.

7b2 marks

Explain why there is a change in the rate of blood flow through the digestive system during exercise.

7c1 mark

The stroke volume is the amount of blood leaving one chamber of the heart per beat.

From which chamber of the heart does this volume of oxygenated blood flow?

  A left atrium
  B left ventricle
  C right atrium
  D right ventricle
7d2 marks

A person has a cardiac output of 4.9 litres per minute. The stroke volume of each heart beat is 70 ml.

Calculate the heart rate.

.................................. beats per minute

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8a
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5 marks

Figure 1 shows the stroke volume at different heart rates of a person who has trained for a marathon and of a person who has not trained for a marathon.fig-9-1bio-2h-june19-qp-gcse-bio

Figure 1

(i)
Compare the effect of heart rate on stroke volume of the person who has trained for a marathon with the person who has not trained for a marathon.
(2)
(ii)
Calculate the cardiac output for the person who has trained for a marathon when the heart rate is 160 beats per minute.
Give the units in your answer.

(3)

8b
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6 marks

Blood from the body enters the heart through the vena cava.

Describe how this blood flows through the heart and lungs to leave the heart through the aorta.

Include references to the chambers of the heart and the relevant valves in your answer.

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9a
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2 marks

Figure 1 shows a cross section of an artery and a vein.fig-6-1bio-2f-june19-qp-gcse-bio

Figure 1

Line A is 8 mm and line B is 4 mm.

State the ratio of the thickness of the artery wall to the thickness of the vein wall.

9b
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2 marks
(i)
Give a reason why veins have valves.

(1)

(ii)
Name the artery that transports oxygenated blood from the heart to the body.
(1)
9c
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5 marks

A scientist investigated the relationship between exercise and the ability to run at 3 metres per second for 20 minutes.

The scientist collected data from six groups of people.
Each group exercised for a different number of hours per week for six months.

There were 100 people in each group.

Figure 2 shows their results.

group number of hours of
exercise per week
number of people who could
run at 3 metres per second
for 20 minutes
A 0 9
B 2 20
C 4 33
D 6 52
E 8 61
F 10 62

Figure 2

(i)
Describe the relationship shown by this data.

(2)

(ii)
Explain why some people’s leg muscles tired quickly and developed cramp when they were running.

(3)

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10
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6 marks

Carbon dioxide is carried in blood plasma.

Human blood also contains red blood cells and white blood cells.

Explain how the structure of red blood cells and white blood cells is related to their function.

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11a
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6 marks

Figure 1 shows the structure and actual size of red blood cells (erythrocytes).fig-9-1bio-2h-nov2021-qp-gcse-bio

Figure 1

(i)
Calculate the image size of the top view of this red blood cell if this cell is magnified 400×.

Give your answer in mm.

(2)

.................................. mm

(ii)
Explain how the shape of a red blood cell is related to its function.

(3)

(iii)
State the role of haemoglobin inside the red blood cell.

(1)

11b
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3 marks

Some blood transfusions contain red blood cells.

Red blood cells are stored in a solution containing 5.0% glucose and 0.9% salt.

Explain why red blood cells cannot be stored in pure water.

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12
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11 marks

Exercise causes changes in the circulation of the blood.

In an investigation, the change in blood flow to different parts of the body during exercise was measured.

All the volunteers used in the study were healthy females of the same age.

Figure 1 shows the results of this investigation.fig-13-1bio-2h-nov2021-qp-gcse-bio

Figure 1

(i)
During exercise, the blood flow to the stomach changes.

Calculate the percentage change in blood flow to the stomach in response to exercise.

Give your answer to the nearest whole number

(3)

.....................................%

(ii)
Suggest two other variables that should be controlled in this investigation.
(2)
1 ......................................
2 ........................................

(iii)
Explain the changes in blood flow, shown in Figure 1, that are caused by exercise.
(6)

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