DP IB Biology: HL

Topic Questions

IBBiology: HLDPTopic Questions8. Metabolism, Cell Respiration & Photosynthesis (HL Only)8.2 Cell Respiration

Syllabus Edition

First teaching 2014

Last exams 2024

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8.2 Cell Respiration

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1
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The diagram below shows a mitochondrion.

Mitochondrion mitochondria structure MCQ

Which letter represents the mitochondrial matrix?

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2
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The diagram shows the four stages of respiration.8-2_q2e

Which row correctly identifies the stages represented in the diagram?

  1 2 3 4
A Glycolysis The link reaction The Krebs cycle The electron transport chain
B The Krebs cycle Glycolysis The link reaction The electron transport chain
C The Krebs cycle The link reaction Glycolysis The electron transport chain
D The Krebs cycle The electron transport chain The link reaction Glycolysis

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3
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The image shows one of the processes of respiration.

q3c_8-2_cell_respiration_medium_ib_hl_biology_sq

Identify the molecule labelled A.

  • A co-transport protein

  • A phospholipid

  • ATP synthase

  • DNA polymerase

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41 mark

Which process is not part of glycolysis?

  • Pyruvate is oxidised and decarboxylated 

  • Triose phosphate is oxidised to glycerate-3-phosphate

  • Fructose bisphosphate is split to form two molecules of triose phosphate

  • NAD is reduced to form NADH + H+

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5
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In 1961 Peter Mitchell proposed a theory which resulted in a paradigm shift in the field of bioenergetics.

Which theory did he develop?

  • The function of REDOX reactions in the electron transport chain

  • The function of oxygen as the final electron acceptor

  • The function of chemiosmosis in synthesis of ATP

  • The importance of the link reaction in progressing from anaerobic to aerobic respiration

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11 mark

In an investigation into the impact of enzyme inhibition on respiration, scientists used a molecule to inhibit transcription of the gene that codes for the enzyme LDHA.

Using the diagram, identify the likely effect this would have on the process of respiration.8-2_q1h

  1. Increased production of lactic acid
  2. A build up of pyruvate in anaerobic conditions
  3. Increased activity of the Krebs cycle in aerobic conditions

  • I, II and III

  • I only

  • II and III

  • II only

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21 mark

The diagram shows the electron transport chain in the membrane of the mitochondria.8-2_q2h

Cyanide is a poison which causes cell death through inhibition of the final electron transport protein when it binds as shown in the diagram.

Which statements correctly describe the impact of cyanide binding to the final transport protein.

  1. A decrease in pH of the intermembrane space
  2. A decrease in production of H2O
  3. An increase in electrochemical gradient
  4. Inhibition of ATP synthesis

  • I, II and IV only

  • II and IV only

  • I and II only

  • II, III and IV

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31 mark

From each molecule of substance X (in the diagram), how many molecules of ATP can be produced?8-2_q3h

  • 17

  • 34

  • 36

  • 18

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41 mark

Which of the following statements about the Krebs cycle are correct?

  1. NAD is oxidised and returned to the link reaction
  2. Citrate is decarboxylated to form a 6 carbon molecule
  3. FADH2 is produced and sent to the electron transport chain
  4. Oxidation of acetyl groups is coupled to reduction of hydrogen carriers.

  • II, III and IV

  • I, II and III

  • II and III only

  • III and IV only

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51 mark

The following steps describe processes involved in oxidative phosphorylation.

  1. Redox reactions drive the movement of protons across the cristae to the intermembrane space
  2. Oxygen molecules combine with protons and electrons to form water
  3. NADH and FADH donate electrons to the first transport protein in the chain
  4. Hydrogen ions (protons) are also released as the coenzymes are oxidised
  5. A high concentration of protons in the intermembrane space creates an electrochemical gradient
  6. Electrons move down the proteins in a series of redox reactions
  7. Protons move down the electrochemical gradient through enzyme ATP synthase

Which of the following shows the correct sequence for these steps?

  • 1 → 4 → 6 → 2 → 5 → 7→ 3

  • 3 → 4 → 6 → 1 → 5 → 7→ 2

  • 3 → 6 → 1→ 5 → 7→ 2 → 4

  • 6 → 3 → 5 → 7→ 2→ 4 → 1

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11 mark

Which row best describes an oxidation reaction?

  Hydrogen Oxygen Electrons Energy
A Loss Gain Loss Released
B Gain Gain Loss Absorbed
C Gain Loss Loss Released
D Loss Gain Loss Absorbed

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21 mark

Which of the following best shows the reduction of NAD?

  • NAD + H₂ →NADH + H⁺

  • NAD⁺ + e⁻ + H⁺ → NADH + H

  • NAD + 2H + 2e⁻ → NADH

  • NAD⁺ + 2e⁻ + 2H⁺ → NADH + H⁺

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31 mark

Which statements correctly describe phosphorylation and dephosphorylation reactions?

  1. The phosphorylation of ADP is an endergonic reaction.
  2. The dephosphorylation of ATP is an endergonic reaction.
  3. The phosphorylation of ADP is a hydrolysis reaction.
  4. The dephosphorylation of ATP is a hydrolysis reaction.

  • I and II

  • II and III

  • I and IV

  • II and IV

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41 mark

Which row shows the products of glycolysis?

  ATP Pyruvate Glucose Reduced NAD
A 4 2 0 2
B 2 2 2 2
C 2 1 1 2
D 2 2 0 2

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51 mark

The diagram below shows a simplified Krebs cycle.

How many times does decarboxylation occur during the Krebs cycle?q5_8-2_cell_respiration_ib_biology_hl_mcq

  • Once

  • Twice

  • Three times

  • Four times

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61 mark

 Which of the following is true of oxidative phosphorylation?

  1. It is the last stage of aerobic respiration.
  2. It takes place on the inner mitochondrial membrane.
  3. It involves chemiosmosis.
  4. It involves the electron transport chain.

  • I, II, and IV

  • II and IV

  • I, II, and III 

  • I, II, III, and IV

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71 mark

The diagram below represents a simplified version of the electron transport chain and chemiosmosis.

 Electron transport chain oxidative phosphorylation MCQ

Which row correctly describes the events labelled 1-4 above?

  1 2 3 4
A Protons move across the cristae into the intermembrane space Protons move across the cristae into the intermembrane space Protons are pumped through ATP synthase ADP is phosphorylated
B Protons move across the cristae into the matrix Protons move across the cristae into the matrix Protons are pumped through ATP synthase ATP is phosphorylated
C Protons move across the cristae into the intermembrane space Protons move across the cristae into the intermembrane space Protons diffuse through ATP synthase ADP is phosphorylated
D Protons move across the cristae into the intermembrane space Protons move across the cristae into the intermembrane space Protons diffuse through ATP synthase ATP is phosphorylated

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81 mark

Chemiosmotic theory was proposed by Nobel Prize winner Peter Mitchell in the 1960s, leading to what is considered to be a paradigm shift. 

Which of the following correctly defines the term paradigm shift?

  • A significant change to the set of ideas that underpin scientific thinking.

  • When a new discovery leads to advances in scientific knowledge.

  • The acceptance of novel and radical ideas.

  • The acceptance of Darwin’s theory of evolution by natural selection.

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91 mark

The diagram below shows a mitochondrion.

cell_respiration_ib_biology_hl_mcq

Where in this organelle is ATP synthase found?

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101 mark

Which row correctly shows the features of a mitochondrion that can be observed and labelled on a drawing using a transmission electron microscope (TEM)?

  Mitochondrion shape RNA and DNA Cristae Intermembrane space
A Yes Yes Yes Yes
B Yes No Yes No
C Yes Yes No Yes
D Yes No Yes Yes

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